应用数学青年讨论班（午餐会）——Discovery and analysis of cell-fate landscape underlying single-cell transcriptome data
报告人：周沛劼（CMLR-PKU）
时间：2023-11-29 11:45-13:30（报告时间12:30-13:30，午餐从11:45开始提供）
地点：智华楼四元厅
摘要：
Single-cell sequencing technologies provide unprecedented resolution for studying the dynamic process of cell-state transitions during development and complex disease. These transitions can be modeled and understood as a multi-scale, stochastic dynamical system on a cell-fate landscape. This could significantly enhance the interpretability and robustness of data mining and biological discovery. However, analyzing high-dimensional, static single-cell RNA-sequencing (scRNA-seq) data with such models can be challenging due to the curse of dimensionality. In this talk, I will discuss how machine learning has enabled us to overcome the challenge and use dynamical system tools to analyze scRNA-seq data. I will first introduce the MuTrans algorithm, which uses a low-dimensional dynamical manifold to identify attractor basins and transition probabilities in snapshot data. I will also present the spliceJAC algorithms, which use non-equilibrium dynamical theory to analyze attractor stability within the landscape and identify transition-driving genes in gene expression and splicing processes. Finally, I will discuss our efforts to construct a time-varying landscape, which interpolates non-stationary time-series scRNA-seq data using Wasserstein-Fisher-Rao metric, unbalanced optimal transport and its neural network-based partial differential equation implementations. Overall, these approaches bridge the model-based and data-driven methods in the modeling and analysis of single-cell biology.
报告人简介：周沛劼，英国威廉希尔公司前沿交叉学科研究院国际机器学习研究中心助理教授，2010-2019年就读于北大威廉希尔计算数学专业，获得学士和博士学位，师从李铁军教授。毕业后在UC Irvine做博士后研究，任访问助理教授，合作导师Qing Nie。他的研究兴趣为数据驱动的计算系统生物学。
讨论班简介：英国威廉希尔公司应用数学青年讨论班 (Applied Mathematics Seminar for Youth) 是一个由英国威廉希尔公司卓越研究生计划组织的学术交流平台。该讨论班定期举办一系列读书会、学术报告，涵盖广泛的应用数学领域，旨在为应用数学领域的员工提供一个互相学习、交流和探讨的机会，促进员工们在该领域的学术成长和思维能力的培养。
报名问卷：我们提供午餐（从11:45开始），需要预定午餐的老师同学请填报名问卷 https://wj.qq.com/s2/13678589/96qs
